NAKAI Lab.

Laboratory of Functional Analysis in silico

Human Genome Center
The Institute of Medical Science
The University of Tokyo

Latest publications

»All

Sanaz Firouzi, Amir Farmanbar, Kenta Nakai, Masako Iwanaga, Kaoru Uchimaru, Atae Utsunomiya, Yutaka Suzuki, and Toshiki Watanabe, Clonality of HTLV-1-infected T-cells as a risk indicator for development and progression of adult T-cell leukemia, blood advances, in press,

Yosvany López, Alexis Vandenbon, Akinao Nose, and Kenta Nakai, Modeling the cis-regulatory modules of genes expressed in developmental stagess of Drosophila melanogaster, PeerJ, 5, e3389 (2017).
(full text)

Amir Farmanbar, Sanaz Firouzi, Sung-Joon Park, Kenta Nakai, Kaoru Uchimaru, and Toshiki Watanabe, Multidisciplinary insight into clonal expansion of HTLV-1-infected cells in adult T-cell leukemia via modeling by deterministic finite automata coupled with high-throughput sequencing. BMC Medical Genomics, 10(1), 4 (2017).
(full text)

Yasunori Sasakura, Yosuke Ogura, Nicholas Treen, Rui Yokomori, Sung-Joon Park, Kenta Nakai, Hidetoshi Saiga, Tetsushi Sakuma, Takashi Yamamoto, Shigeki Fujiwara, and Keita Yoshida, Transcriptional regulation of a horizontally transferred gene from bacterium to chordate. Proc. Royal Soc. B. 283(1845), pii: 20161712 (2016).
(PubMed)

Josep Basha Gutierrez and Kenta Nakai, A study on the application of topic models to motif finding algorithms. BMC Bioinformatics 17(Suppl. 19), 1364 (2016).
(full text)

Myungjin Moon and Kenta Nakai, Stable feature selection based on the ensemble L₁-norm support vector machine for biomarker discovery. BMC Genomics 17(Suppl. 13), 3320 (2016).
(full text)

Satoru Onizuka, Takanori Iwata, Sung-Joon Park, Kenta Nakai, Masayuki Yamato, Teruo Okano, and Yuichi Izumi, ZBTB16, a downstream target gene of Osterix, regulates osteoblastogenesis of human multipotent mesenchymal stromal cells. J. Cell. Biochem., 117(10), 2423-2434 (2016).
(PubMed)

Kazuhiro Fukumura, Shunichi Wakabayashi, Naoyuki Kataoka, Hiroshi Sakamoto, Yutaka Suzuki, Kenta Nakai, Akila Mayeda, and Kunio Inoue, The exon junction complex controls the efficient and faithful splicing of a subset of transcripts involved in miotic cell-cycle progression. Int. J. Mol. Sci., 17(8), 1153 (2016).
(full text)

Sung-Joon Park and Kenta Nakai, Chapter 7: Computational inference of gene regulation from whole-transcriptome analysis of early embryos. in (Ivan V. Ivanov, Xiaoning Qian, and Ranadip Pal eds.) Emerging Research in the Analysis and Modeling of Gene Regulatory Networks, pp.241-279, IGI Global, ISBN: 9781522503538 (2016).

Yuzuru Sasamoto, Ryuhei Hayashi, Sung-Joon Park, Mihoko Saito-Adachi, Yutaka Suzuki, Satoshi Kawasaki, Andrew Quantock, Kenta Nakai, Motokazu Tsujikawa, and Kohji Nishida, PAX6 isoforms, along with reprogramming factors, differentially regulate the induction of cornea-specific genes. Sci. Rep., 6, 20807 (2016).
(abstract)

Sung-Joon Park, Mihoko Saito-Adachi, Yusuke Komiyama, and Kenta Nakai, Advances, practice, and clinical perspectives in high-throughput sequencing, Oral Diseases, 22(5), 353-364 (2016).
(PubMed)

Rui Yokomori, Kotaro Shimai, Koki Nishitsuji, Yutaka Suzuki, Takehiro G. Kusakabe, and Kenta Nakai, Genome-wide identification and characterization of transcription start sites and promoters in the tunicate Ciona intestinalis. Genome Res., 26, 140-150 (2016).
(abstract)

Sung-Joon Park, Yusuke Komiyama, Hirofumi Suemori, Akihiro Umezawa, and Kenta Nakai, OpenTein: a database of digital whole-slide images of stem cell-derived teratomas. Nucl. Acids Res., 44(D1), D1000-D1004 (2016).
(full text)

Yosvany López, Kenta Nakai, and Ashwini Patil, HitPredict version 4 - comprehensive reliablity scoring of physical protein-protein interactions from more than 100 species, DATABASE, 2015, bav117 (2015).
(full text).

Kuo-ching Liang, Ashwini Patil, and Kenta Nakai, Discovery of intermediary genes between pathways using sparse regression. PLoS One, 10(9), e0137222 (2015).
(full text).

Jong-Hun Lee, Sung-Joon Park, and Kenta Nakai, An integrative approach for efficient analysis of whole genome bisulfite sequencing data. BMC Genomics 16(Suppl 12), S14 (2015)
(full text).

Josep Basha Gutierrez, Martin Frith, and Kenta Nakai, A genetic algorithm for motif finding based on statistical significance. Bioinformatics and Biomedical Engineering (Third International Conference, IWBBIO 2015, Granada, Spain, April 15-17, 2015, Proceedings, Part I), Springer, LNCS 9043, pp.438-449 (2015).

Ayako Suzuki, Hiroyuki Wakaguri, Riu Yamashita, Shin Kawano, Katsuya Tsuchihara, Sumio Sugano, Yutaka Suzuki, and Kenta Nakai, DBTSS as an integrative platform for transcriptome, epigenome and genome sequence variation data. Nucl. Acids Res., 43, D87-D91 (2015).
(full text).

Sung-Joon Park, Katsuhiko Shirahige, Miho Ohsugi and Kenta Nakai, DBTMEE: a database of transcriptome in mouse early embryos. Nucl. Acids Res., 43, D771-D776 (2015).
(full text).

Lucky R. Runtuwene, Kaori Noguchi, Akinori Tokunaga, Takashi Kobayashi, Kenta Nakai, and Yuki Eshita, Vector competence of Aedes aegypti to dengue virus. Urban Pest Management, 4(1), 1-14 (2014),

Ashwini Patil and Kenta Nakai, TimeXNet: Identifying active gene sub-networks using time-course gene expression profiles, BMC Syst. Biol., 8(Suppl.4), S2 (2014).
(full text).

Yosvany López, Alexis Vandenbon, and Kenta Nakai, A Set of Structural Features Defines the Cis-Regulatory Modules of Antenna-Expressed Genes in Drosophila melanogaster, PLoS One 9(8), e104342 (2014).
(full text)

Sanaz Firouzi, Yosvany López, Yutaka Suzuki, Kenta Nakai, Sumio Sugano, Tadanori Yamochi and Toshiki Watanabe, Development and validation of a new high-throughput method to investigate the clonality of HTLV-1-infected cells based on provirus integration sites, Genone Medicine, 6, 46 (2014).
(full text)

Kenta Nakai, Overview of Bioinformatics Research in Japan, Asia Pacific Biotech, 18(9), 35-37 (2014).

Kyungtaek Lim, Ichizo Kobayashi, and Kenta Nakai, Alterations in rRNA-mRNA interaction during plastid evolution, Mol. Biol, Evol., 31(7), 1728-1740 (2014).
(PubMed)

Sung-Joon Park, Terumasa Umemoto, Mihoko Saito-Adachi, Yoshiko Shiratsuchi, Masayuki Yamato, and Kenta Nakai, Computational promoter modeling identifies the modes of transcriptional regulation in hematopoietic stem cells, PLoS One, 9(4), e93853 (2014).
(full text)

Alok Sharma, Abdollah Dehzangi, James Lyons, Seiya Imoto, Satoru Miyano, Kenta Nakai, and Ashwini Patil, Evaluation of sequence features from intrinsically disordered regions for the estimation of protein function, PLoS One, 9(2), e89890 (2014).
(full text)

Asmaa Elzawahry, Ashwini Patil, Yutaro Kumagai, Yutaka Suzuki, and Kenta Nakai, Innate immunity interactome dynamics, Gene Regulation and Systems Biology, 8, 1-15 (2014)
(abstract & pdf)

Kuo-ching Liang, Yutaka Suzuki, Yutaro Kumagai, and Kenta Nakai, Analysis of changes in transcription start site distribution by a classification approach, Gene, 537(1), 29-40 (2014); published online 31 December 2013
(full text)

Sung-Joon Park, Makiko Komata, Fukashi Inoue, Kaori Yamada, Kenta Nakai, Miho Ohsugi and Katsuhiko Shirahige, Inferring the choreography of parental genomes during fertilization from ultralarge-scale whole-transcriptome analysis, Genes Dev., 27(24), 2736-2748 (2013).
(full text)

Ashwini Patil, Yutaro Kumagai, Kuo-ching Liang, Yutaka Suzuki, and Kenta Nakai, Linking transcriptional changes over time in stimulated dendritic cells to identify gene networks activated during the innate immune response, PLoS Comput. Biol., 9(11), e1003323 (2013); Epub Nov.7, 2013
(full text)

Yosvany López, Ashwini Patil, and Kenta Nakai, Identification of novel motif patterns to decipher the promoter architecture of co-expressed genes in Arabidopsis thaliana, BMC Systems Biol., 7(Suppl 3): S10 (2013).
(full text)

Yasunori Sasakura, Nicolas Sierro, Kenta Nakai, Kazuo Inaba, and Takehiro G. Kusakabe, Chapter 4: Genome structures, functional genomics, and proteomics in ascidians, in (Denny, P. & Kole, C. eds.) Genome mapping and genomics in laboratory animals, pp.87-132, Springer (2013).

Yuko Makita and Kenta Nakai, Chapter 8: Bacillus subtilis transcriptional network, in (M. Madan Babu ed.) Bacterial Gene Regulation and Transcriptional Networks, pp.155-165, Caister Academic Press (ISBN: 978-1-908230-14-0) (2013)

Rie Kusakabe, Saori Tani, Koki Nishitsuji, Miyuki Shindo, Kohji Okamura, Yuki Miyamoto, Kenta Nakai, Yutaka Suzuki, Takehiro G. Kusakabe, and Kunio Inoue, Characterization of the compact bicistronic microRNA precursor, miR-1/miR-133, expressed specifically in Ciona muscle tissues, Gene Expression Patterns, 13(1-2), 43-50.(2013)
(PubMed)

Manabu Ozawa, Miki Sakatani, JiQiang Yao, Savita Shanker, Fahong Yu, Riu Yamashita, Shuichi Wakabayashi, Kenta Nakai, Kyle B Dobbs, Mateus J. Sudano, William G. Farmerie, and Peter J. Hensen, Global gene expression of the inner cell mass and trophectoderm of the bovine blastcyst, BMC Dev. Biol., 12, 33 (2012)
(full text)

Naganari Ohkura, Masahide Hamaguchi, Hiromasa Morikawa, Kyoko Sugimura, Atsushi Tanaka, Yoshinaga Ito, Motonao Osaki, Yoshiaki Tanaka, Riu Yamashita, Naoko Nakano, Jochen Huehn, Hans-Joerg Fehling, Tim Sparwasser, Kenta Nakai, and Shimon Sakaguchi, T cell receptor stimulation-induced epigenetic changes and Foxp3 expression are independent and complementary events required for Treg cell development, Immunity, 37(5), 785-799 (2012).
(PubMed)

Harry Amri Moesa, Shunichi Wakabayashi, Kenta Nakai, and Ashwini Patil, Chemical composition is maintained in poorly conserved intrinsically disordered regions and suggests a means for their classification. Mol. Biosystems, 8(12), 3262-3273 (2012); published online on 18 Oct 2012
(full text)

Sumiyo Morita, Ryou-u Takahashi, Riu Yamashita, Atsushi Toyoda, Takuro Horii, Mika Kimura, Asao Fujiyama, Kenta Nakai, Shoji Tajima, Ryo Matoba, Takahiro Ochiya and Izuho Hatada, Genome-wide analysis of DNA methylation and expression of microRNAs in breast cancer cells, Int. J. Mol. Sci., 13(7), 8259-8272 (2012).
(abstract)

Daniel Kraut, Eitan Israeli, Erin Schrade, Ashwini Patil, Kenta Nakai, Dhaval Nanavati, Tomonao Inobe, and Andreas Matouschek, Sequence- and species-dependence of proteasomal processivity, ACS Chemical Biology,7(8), 1444-1453 (2012); epub 2012 Jun. 22.
(abstract)

Kouichi Kimura, Asako Koike, and Kenta Nakai, A Bit-parallel dynamic programming algorithm suitable for DNA sequence alignment, J. Bioinformatics and Computational Biology, 10(4), 1250002 (2012); published online on Feb. 2, 2012.
(abstract)

Riu Yamashita, Sumio Sugano, Yutaka Suzuki, and Kenta Nakai, DBTSS: database of transcriptional start sites progress report in 2012, Nucl. Acids Res., 40(Database Issue), D150-154 (2012); published online on Nov. 15, 2011.
(full text)

Ashwini Patil, Shunsuke Teraguchi, Huy Dinh, Kenta Nakai, and Daron M. Standley, Functional annotation of intrinsically disordered domains by their amino acid content using IDD Navigator, Pacific Symposium on Biocomputing 17, 164-175 (2012)
(pdf)

Ashwini Patil, Kenta Nakai, and Kengo Kinoshita, Assessing the utility of gene co-expression stability in combination with correlation in the analysis of protein-protein interaction networks, BMC Genomics 12(Suppl. 3), S19 (2011).
(full text)

Kohji Okamura, Riu Yamashita, Noriko Takimoto, Koki Nishitsuji, Yutaka Suzuki, Takehiro G. Kusakabe, and Kenta Nakai, Profiling ascidian promoters as the primordial type of vertebrate promoter, BMC Genomics 12(Suppl. 3), S7 (2011).BEST PAPER AWARD in InCoB211
(full text)

Kouichi Kimura, Asako Koike and Kenta Nakai, Seed-set construction by equi-entropy partitioning for efficient and sensitive short-read mapping, Algorithms in Bioinformatics in (T.M.Przytycka and M.-F. Sagot ed.) Lecture Notes in Computer Science, 6833, 151-162 (2011). (ISBN: 978-3-642-23037-0).

Daisuke Ohshima, Junwen Qin, Hiroyasu Konnno, Akihisa Hirosawa, Takuma Shiraishi, Hiromi Yanai, Yusuke Shimo, Nobuko Akiyama, Riu Yamashita, Kenta Nakai, and Jun-ichiro Inoue, RANK signaling induces interferon-stimulated genes in the fetal thymic stroma, Biochem. Biophys. Res. Comm., 408(4), 530-536 (2011).
(PubMed)

Takuma Irie, Sung-Joon Park, Riu Yamashita, Masahide Seki, Tetsushi Yada, Sumio Sugano, Kenta Nakai, and Yutaka Suzuki, Predicting promoter activities of primary human DNA sequences, Nucl. Acids Res., 39(11), e75 (2011); published online on April 12, 2011.
(full text)

Riu Yamashita, Nuankanya P Sathira, Akinori Kanai, Kousuke Tanimoto, Takako Arauchi, Yoshiaki Tanaka, Shin-ichi Hashimoto, Sumio Sugano, Kenta Nakai, and Yutaka Suzuki, Genome-wide characterization of transcription start sites in humans by integrative transcriptome analysis, Genome Res., 21(5), 775-789 (2011); published online on March 3, 2011.
(abstract)

Parul Khare, Sanra I. Mortimer, Cynthia L. Cleto, Kohji Okamura, Yutaka Suzuki, Takehiro Kusakabe, Kenta Nakai, Thomas H. Meedel, and Kenneth E. M. Hastings, Cross-validated methods for promoter/transcription start site mapping in SL trans-spliced genes, established using the Ciona intestinalis troponin I gene, Nucleic Acids Res., 39(7), 2638-2648 (2011); published online on November 24, 2010.
(full text)

»All